Epigenetic reprogramming in mouse and human primordial germ cells

Primordial germ cells (PGCs) are the precursors of sperm and eggs. They undergo genome-wide epigenetic reprogramming to erase epigenetic memory and reset the genomic potential for totipotency. Global DNA methylation erasure is a crucial part of epigenetic resetting when DNA methylation levels decrea...

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Veröffentlicht in:	Experimental & molecular medicine 2024, 56(0), , pp.2578-2587
Hauptverfasser:	Lee, Sun-Min, Surani, M. Azim
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 45/23 45/91 631/136/2434 631/208/176 Animals Artificial intelligence Biomedical and Life Sciences Biomedicine Cell culture Cellular Reprogramming - genetics Demethylation DNA biosynthesis DNA Methylation Eggs Epigenesis, Genetic Epigenetics Fertilization Gene Expression Regulation, Developmental Gene regulation Genomes Genomics Germ cells Germ Cells - cytology Germ Cells - metabolism Histones Histones - metabolism Humans Infertility Medical Biochemistry Mice Molecular Medicine Review Review Article Sperm Stem Cells 생화학
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Zusammenfassung:	Primordial germ cells (PGCs) are the precursors of sperm and eggs. They undergo genome-wide epigenetic reprogramming to erase epigenetic memory and reset the genomic potential for totipotency. Global DNA methylation erasure is a crucial part of epigenetic resetting when DNA methylation levels decrease across the genome to
ISSN:	2092-6413 1226-3613 2092-6413
DOI:	10.1038/s12276-024-01359-z