Severity of microvascular invasion does matter in hepatocellular carcinoma prognosis: Editorial on "Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging"

[...]the authors indicated that a nonsmooth tumor margin may be useful for excluding the presence of severe MVI, as it showed a high sensitivity (88.2%) and negative predictive value (90.7%) for detecting severe MVI. Due to the retrospective nature of this investigation, there is a chance that the liver tumor specimen processing methodology was inconsistent throughout the study period. [...]this study was conducted in a cohort of HCC patients with a predominant etiology of hepatitis B virus and preserved liver function. [...]prognostic significance of MVI categorization and radiologic features indicative of MVI should be further validated in future studies to confirm their predictive values in independent cohorts of HCC patients with different liver disease etiology and degrees of liver dysfunction. Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea. 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma.