The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test

M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. Healthy volunteers and pa...

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Veröffentlicht in:Gut and liver 2015, 9(5), , pp.641-648
Hauptverfasser: Kim, Yong Cheol, Kim, Jeong Ho, Cheung, Dae Young, Kim, Tae Ho, Jun, Eun Jung, Oh, Jung-Whan, Kim, Chang Whan, Chung, Woo Chul, Kim, Byung-Wook, Kim, Sung Soo, Kim, Jin Il, Park, Soo-Heon, Kim, Jae Kwang
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Sprache:eng
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Zusammenfassung:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA). A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl13457