Correspondence on Letter regarding "Both liver parenchymal and non-parenchymal cells express JCAD proteins under various circumstances"

The authors showed that junctional protein associated with coronary artery disease (JCAD) and YAP were positive in CK-19-positive cells known as bile duct epithelial cells (BECs) in newly formed bile ducts through immunohistochemical staining in liver tissue of primary biliary cholangitis patients [1]. [...]it is difficult to accurately determine its function simply by the level of expression in the tissue, so additional research will be needed to determine the role of JCAD expression in BECs in the future. [...]on the one hand, increased expression of JCAD promotes the regeneration of hepatocytes and bile duct epithelial cells [1,2]. but also promotes the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma and activates hepatic stellate cells in cholestatic liver disease [3,4]. [...]through further research on these issues in the future, we hope to accumulate knowledge about the mechanism and role of JCAD in various liver diseases and apply it to treatment.