Exploring the Association between Thyroid Function and Frailty: Insights from Representative Korean Data

This study investigates the association between thyroid function and frailty in the old patients using representative data. The study was conducted using data from the Korea National Health and Nutrition Examination Survey conducted from 2013 to 2015. The study population included 2,416 participants...

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Veröffentlicht in:Endocrinology and metabolism (Seoul) 2023, 38(6), , pp.729-738
Hauptverfasser: Lee, Youn-Ju, Kim, Min-Hee, Lim, Dong-Jun, Lee, Jung-Min, Chang, Sang Ah, Lee, Jeongmin
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Sprache:eng
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Zusammenfassung:This study investigates the association between thyroid function and frailty in the old patients using representative data. The study was conducted using data from the Korea National Health and Nutrition Examination Survey conducted from 2013 to 2015. The study population included 2,416 participants aged 50 years and older with available thyroid function test data. Frailty assessment was performed using the Fried frailty phenotype. The prevalence of frailty was analyzed across different thyroid diseases and thyroid function parameters. The significant association between thyroid dysfunction and frailty was observed in overt hyperthyroidism and subclinical hyperthyroidism. After adjusting for various factors, the association between thyroid dysfunction and frailty remained significant. On the other hand, overt hypothyroidism did not show a significant association with frailty in the adjusted analysis. For individuals with overt hyperthyroidism and subclinical hyperthyroidism, higher levels of free thyroxine (FT4) were significantly associated with an increased risk of frailty (aOR >999; 95% CI, >999 to 999). Among individuals with overt hypothyroidism, lower level of FT4 levels and high thyrotropin (TSH) levels showed a significant association with frailty risk (FT4: aOR,
ISSN:2093-596X
2093-5978
2093-5978
DOI:10.3803/EnM.2023.1769