노니 ethyl acetate 분획의 예쁜꼬마선충에 대한 항산화 효과

The ethanol extract of Morinda citrifolia was studied for antioxidative activity using a Caenorhabditis elegans model system. Ethyl acetate fraction of the ethyl alcohol extract showed the strongest DPPH, ABTS, superoxide radical scavenging activity. SOD and catalase enzymes, which confirm antioxida...

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Veröffentlicht in:생약학회지(Korean Journal of Pharmacognosy) 2023, 54(3), 214, pp.112-119
Hauptverfasser: 문지수(Ji Su-Mun), 김현지(Hyeoun ji-Kim), 백향임(Hyang Im-Beak), 마상용(Sang Yong-Ma), 김대근(Dae Keun-Kim), 오석흥(Suk Heung-Oh), 김준형(Jun Hyeong-Kim)
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Sprache:kor
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Zusammenfassung:The ethanol extract of Morinda citrifolia was studied for antioxidative activity using a Caenorhabditis elegans model system. Ethyl acetate fraction of the ethyl alcohol extract showed the strongest DPPH, ABTS, superoxide radical scavenging activity. SOD and catalase enzymes, which confirm antioxidant enzyme activity in Caenorhabditis elegans, and reactive oxygen species (ROS), which can confirm the degree of oxidative stress resistance, were tested using the ethyl acetate fractions. Furthermore, in order to verify if regulation of stress response gene is responsible for the increased stress resistance of C. elegans which treated by the ethyl acetate fraction, we checked SOD-3 expression using a transgenic strain. Consequently, the ethyl acetate fraction of Morinda citrifolia Linn. increased the SOD and catalase activities in concentration dependent way in C. elegans, reduced ROS accumulation dose dependently. Besides, the ethyl acetate fraction-treated CF1553 worms showed more higher SOD-3::GFP intensity than the control group. KCI Citation Count: 0
ISSN:0253-3073
2288-9299
DOI:10.22889/KJP.2023.54.3.112