Risk of Diabetic Retinopathy between Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists

Risk of Diabetic Retinopathy between Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists

To compare risk of diabetic retinopathy (DR) between patients taking sodium-glucose cotransporter-2 inhibitors (SGLT2is) and those taking glucagon-like peptide-1 receptor agonists (GLP1-RAs) in routine care. This retrospective cohort study emulating a target trial included patient data from the mult...

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Veröffentlicht in:Diabetes & metabolism journal 2023, 47(3), 197, pp.394-404
Hauptverfasser: Lin, Tzu-Yi, Kang, Eugene Yu-Chuan, Shao, Shih-Chieh, Lai, Edward Chia-Cheng, Garg, Sunir J, Chen, Kuan-Jen, Kang, Je-Ho, Wu, Wei-Chi, Lai, Chi-Chun, Hwang, Yih-Shiou
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
diabetic retinopathy
Diabetic Retinopathy - complications
Diabetic Retinopathy - epidemiology
Glucagon-Like Peptide 1
glucagon-like peptide-1 receptor
Glucagon-Like Peptide-1 Receptor - agonists
Glucose
Humans
Hypoglycemic Agents - therapeutic use
Original
Retrospective Studies
Sodium - therapeutic use
sodium-glucose transporter 2 inhibitors
Sodium-Glucose Transporter 2 Inhibitors - adverse effects
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Zusammenfassung:To compare risk of diabetic retinopathy (DR) between patients taking sodium-glucose cotransporter-2 inhibitors (SGLT2is) and those taking glucagon-like peptide-1 receptor agonists (GLP1-RAs) in routine care. This retrospective cohort study emulating a target trial included patient data from the multi-institutional Chang Gung Research Database in Taiwan. Totally, 33,021 patients with type 2 diabetes mellitus using SGLT2is and GLP1-RAs between 2016 and 2019 were identified. 3,249 patients were excluded due to missing demographics, age
ISSN:2233-6079
2233-6087
DOI:10.4093/dmj.2022.0221