The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells....

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Veröffentlicht in:Mycobiology 2010, 38(1), , pp.46-51
Hauptverfasser: Jo, W.S., Dong-A University College of Medicine, Busan, Republic of Korea, Choi, Y.J., Dong-A University College of Medicine, Busan, Republic of Korea, Kim, H.J., Dong-A University College of Medicine, Busan, Republic of Korea, Lee, J.Y., Cheong-Won Farm, Gimhae, Republic of Korea, Nam, B.H., Pusan National University College of Natural Sciences, Busan, Republic of Korea, Lee, J.D., Pusan National University College of Natural Sciences, Busan, Republic of Korea, Lee, S.W., Dong-A University College of Medicine, Busan, Republic of Korea, Seo, S.Y., Dong-A University College of Medicine, Busan, Republic of Korea, Jeong, M.H., Dong-A University College of Medicine, Busan, Republic of Korea
Format: Artikel
Sprache:eng
Schlagworte:
Anti-inflammatory activity
Cordyceps militaris
LIPOPOLISACARIDOS
LIPOPOLYSACCHARIDE
LIPOPOLYSACCHARIDES
NITRIC OXIDE
OXIDO NITRICO
OXYDE NITRIQUE
Pro-inflammatory cytokines
RAW 264.7 cell
생물학
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Beschreibung
Zusammenfassung:The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-α and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.
ISSN:1229-8093
2092-9323
DOI:10.4489/MYCO.2010.38.1.046