柴胡淸肝散 투여가 아토피 피부염을 유발한 동물모델의 각질층 기능회복에 미치는 영향

Objective : Administering the Sihocheonggan-san(SC) extract on to the control (CON) is to study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide and this study is done through forcing injury to mice's back skin which are lipid protect formation in stratum corneum. Materials and Methods : The CON which caused intentionally using the external application on the mice's back skin was used the SC. The change of leukocytes in vasculature has been identified through optima 5.2 and student t-test and the results were made into dermal foramtion graph. Results : After dispensing SC extract into the CON, the dermal injury was decreased. Especially, recover of lipid protection formation which include lipid and ceramide in stratum corneum is suppressing acute inflammation that some factors are PKC, TNF-α, IL-12B which controled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and the decrese of degranulated mast cell. In addition, the decrease of epithelial injury also caused the growth of cell to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease CON. Conclusion : Thus, SC has effect on CON suppressing the dermal injury through recovering of lipid protection formation in stratum corneum. KCI Citation Count: 15