Circadian regulation of GABA A receptor function by CKI -CKIδ in the rat suprachiasmatic nuclei

The type A GABA receptors are thought to mediate synchronization of clock cell activity within the suprachiasmatic nuclei (SCN). Here we report that casein kinases I and δ (CKI and CKIδ), the crucial clock regulators, form a complex with GABAA receptors and inhibit the receptors' function within the SCN according to a circadian rhythm. These results indicate that circadian variation of the kinase-receptor association may mediate regulation of GABAA receptor function by CKI -CKIδ in the SCN.