Characterization of the Biomechanical Behavior of the Optic Nerve Sheath

Characterization of the Biomechanical Behavior of the Optic Nerve Sheath

A major priority in current space medicine research is to characterize the mechanisms in Visual Impairment and Intracranial Pressure (VIIP) syndrome, a group of ophthalmic changes that occur in some astronauts following long-duration spaceflight [1]. It is hypothesized that microgravity-induced ceph...

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Hauptverfasser: Raykin, Julia, Wang, Roy, Forte, Taylor E., Feola, Andrew, Samuels, Brian, Myers, Jerry, Nelson, Emily, Gleason, Rudy, Ethier, C. Ross
Format: Other
Sprache:eng
Schlagworte:
Aerospace Medicine
Numerical Analysis
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Zusammenfassung:A major priority in current space medicine research is to characterize the mechanisms in Visual Impairment and Intracranial Pressure (VIIP) syndrome, a group of ophthalmic changes that occur in some astronauts following long-duration spaceflight [1]. It is hypothesized that microgravity-induced cephalad fluid shifts lead to increases in intracranial pressure (ICP), which drives maladaptive remodeling of the optic nerve sheath (ONS). In this study, we investigated the effects of mechanical loading on the porcine ONS to better understand the mechanical response of the ONS to increased ICP.