Duodenal Microbiota in Stunted Undernourished Children with Enteropathy

Duodenal and plasma biomarkers of environmental enteric dysfunction that were identified through analyses of duodenal biopsy samples and the plasma of growth-stunted children were found to induce enteropathy of the small intestine in gnotobiotic mice.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-07, Vol.383 (4), p.321-333
Hauptverfasser:	Chen, Robert Y, Kung, Vanderlene L, Das, Subhasish, Hossain, M. Shabab, Hibberd, Matthew C, Guruge, Janaki, Mahfuz, Mustafa, Begum, S.M. Khodeza Nahar, Rahman, M. Masudur, Fahim, Shah Mohammad, Gazi, M. Amran, Haque, Rashidul, Sarker, Shafiqul A, Mazumder, Ramendra N, Di Luccia, Blanda, Ahsan, Kazi, Kennedy, Elizabeth, Santiago-Borges, Jesus, Rodionov, Dmitry A, Leyn, Semen A, Osterman, Andrei L, Barratt, Michael J, Ahmed, Tahmeed, Gordon, Jeffrey I
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Bacteria Bacteria - isolation & purification Bangladesh Biomarkers Biopsy Children Deoxyribonucleic acid DNA Duodenoscopy Duodenum - microbiology Duodenum - pathology Endoscopy Environmental Illness - complications Fecal microflora Feces Feces - microbiology Female Gastrointestinal Microbiome Germ-Free Life Germfree Gnotobiotic Growth Growth Disorders - etiology Growth Disorders - microbiology Humans Hypotheses Hypothesis testing Infant Infant Nutrition Disorders - complications Inflammatory Bowel Diseases - complications Insulin-Like Growth Factor I - analysis Intervention Intestinal Diseases - complications Intestinal microflora Male Mice Mice, Inbred C57BL Microbiota Mucosa Multivariate Analysis Pancreatitis-Associated Proteins - analysis Plasma Plasma proteins Proteins Proteome - analysis Ribosomal DNA Small intestine Strains (organisms) Undernutrition
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Beschreibung
Zusammenfassung:	Duodenal and plasma biomarkers of environmental enteric dysfunction that were identified through analyses of duodenal biopsy samples and the plasma of growth-stunted children were found to induce enteropathy of the small intestine in gnotobiotic mice.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1916004