Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

Breast cancer risk has been attributed to variation in many genes, and gene panels for clinical testing are correspondingly large. But how much risk can be reliably attributed to variation in specific genes? This large study provides answers.

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Veröffentlicht in:	The New England journal of medicine 2021-02, Vol.384 (5), p.428-439
Hauptverfasser:	Dorling, Leila, Carvalho, Sara, Allen, Jamie, Gonzalez-Neira, Anna, Luccarini, Craig, Wahlstrom, Cecilia, Pooley, Karen A., Parsons, Michael T., Fortuno, Cristina, Wang, Qin, Bolla, Manjeet K., Dennis, Joe, Keeman, Renske, Alonso, M. Rosario, Alvarez, Nuria, Herraez, Belen, Fernandez, Victoria, Nunez-Torres, Rocio, Osorio, Ana, Valcich, Jeanette, Li, Minerva, Torngren, Therese, Harrington, Patricia A., Baynes, Caroline, Conroy, Don M., Decker, Brennan, Fachal, Laura, Mavaddat, Nasim, Ahearn, Thomas, Aittomaki, Kristiina, Antonenkova, Natalia N., Arnold, Norbert, Arveux, Patrick, Ausems, Margreet G. E. M., Auvinen, Paivi, Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Bialkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia V., Bogdanova-Markov, Nadja, Bojesen, Stig E., Bonanni, Bernardo, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Bremer, Michael, Briceno, Ignacio, Bruning, Thomas, Burwinkel, Barbara, Cameron, David A., Camp, Nicola J., Campbell, Archie, Carracedo, Angel, Castelao, Jose E., Cessna, Melissa H., Chanock, Stephen J., Christiansen, Hans, Collee, J. Margriet, Cordina-Duverger, Emilie, Cornelissen, Sten, Czene, Kamila, Doerk, Thilo, Ekici, Arif B., Engel, Christoph, Eriksson, Mikael, Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, Foersti, Asta, Gabrielson, Marike, Gago-Dominguez, Manuela, Georgoulias, Vassilios, Gil, Fabian, Giles, Graham G., Glendon, Gord, Garcia, Encarna B. Gomez, Alnaes, Grethe I. Grenaker, Guenel, Pascal, Hadjisavvas, Andreas, Haeberle, Lothar, Hahnen, Eric, Hall, Per, Hamann, Ute, Harkness, Elaine F., Hartikainen, Jaana M., Hartman, Mikael, He, Wei, Heemskerk-Gerritsen, Bernadette A. M., Hillemanns, Peter, Hogervorst, Frans B. L., Hollestelle, Antoinette, Ho, Weang Kee, Hooning, Maartje J., Howell, Anthony, Humphreys, Keith, Idris, Faiza, Jakubowska, Anna, Jung, Audrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age Factors Aged Aged, 80 and over Association analysis Bayesian analysis BRCA1 protein BRCA2 protein Breast cancer Breast Neoplasms - genetics Cancer and Oncology Cancer och onkologi Clinical Medicine Confidence intervals Estimates Estrogen receptors Family medical history Female General & Internal Medicine Genetic counseling Genetic Predisposition to Disease - genetics Genetic screening Genetic Variation Humans Klinisk medicin Life Sciences & Biomedicine Logistic Models Medical and Health Sciences Medicin och hälsovetenskap Medicine, General & Internal Middle Aged Mutation, Missense Odds Ratio p53 Protein Pathogenicity Population Proteins Risk Science & Technology Sequence Analysis, DNA Statistical analysis Tumors Womens health Young Adult
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Beschreibung
Zusammenfassung:	Breast cancer risk has been attributed to variation in many genes, and gene panels for clinical testing are correspondingly large. But how much risk can be reliably attributed to variation in specific genes? This large study provides answers.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1913948