Effect of Byakko-ka-ninjin-to and Gorei-san in STZ-induced diabetic saliva flow disorders mouse

Diabetes mellitus (DM) often accompany the mouth dryness symptom. Recently, the therapy of DM with the Japanese traditional medicine is noted and the research is continued. In this study, the effects of Byakko-ka-ninjin-to and Gorei-san on salivary flow were examined in streptozocin (STZ)-induced diabetic mice. The blood glucose level was maintained at 300 mg/dL from 7 to 21 days after administration of STZ. At day 21, salivary flow was significantly decreased in mice administered with STZ compared with control group. Administration of Byakko-ka-ninjin-to or Gorei-san to the STZ-induced DM model mice was recovered from hyperglycemia and saliva flow disorders.