In Vitro Toxicity Test for Biomaterials：Inhibition of Metabolic Cooperation in V79 Cells by Metal Ions and Antioxidants Including Tumor Promotors

In Vitro Toxicity Test for Biomaterials：Inhibition of Metabolic Cooperation in V79 Cells by Metal Ions and Antioxidants Including Tumor Promotors

Thte effects of various metal ions and phenolic antioxidants on metabolic cooperation in the hypoxanthine-guanine phosphoribosyl transferase system were surveyed. Among 11 kinds of metal ions, 5 metal ions, such as Cd, Cu, Zn, Pb and Li inhibited metabolic cooperation. We found a correlation between...

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Veröffentlicht in:Alternatives to Animal Testing and Experimentation 1993, Vol.2 (2), p.84-84
Hauptverfasser: Hideyo Hata, Toshie Tsuchiya, Yoshiaki Ikarashi, Masato Fujimaki, Akitada Nakamura
Format: Artikel
Sprache:jpn
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Zusammenfassung:Thte effects of various metal ions and phenolic antioxidants on metabolic cooperation in the hypoxanthine-guanine phosphoribosyl transferase system were surveyed. Among 11 kinds of metal ions, 5 metal ions, such as Cd, Cu, Zn, Pb and Li inhibited metabolic cooperation. We found a correlation between the teratogenicity and the inhibitory activity on metabolic cooperation by metal ions. In the case of 6 antioxidants tested, 5 chemicals inhibited metabolic cooperation. BHT, a tumor promoter, showed the inhibitory activity at higher concentration than the other four antioxidants.
ISSN:1344-0411