Large-Cell Undifferentiated Carcinoma of the Submandibular Gland

Occurrence of large-cell undifferentiated carcinoma in the submandubular gland is uncommon. A 52-year-old man with a 30-mm tumor underwent radical resection of the left submandibular gland together with selective dissection of enlarged ipsilateral cervical nodes followed by postoperative radiotherapy. After histologic examination identified the submandibular gland mass as large-cell undifferentiated carcinoma, selective dissection of enlarged contralateral cervical nodes was performed. The patient showed no evidence or of distant metastasis at 24 months after initial treatment.