Effect of Etoposide on Cell Cycle Progression in L1210 Murine Ascites Tumor

We examined the effect of etoposide on cell cycle progression in L1210 murine ascites tumor. Cell cycle analysis was examined by flow cytometer. At 3 and 6 hr after administration of etoposide, the percentage of the S-phase increased to more than 1.3-fold as compared to that of the control. At 10 hr, cells were piled up in G2+M Phase, and S-phase decreased. Since ara-C is a drug with a cell cycle S-phase specific action, these results might explain the enhanced incorporation of ara-C by pretreatment with etoposide that we reported previously.