VIRUS PARTICLES IN SPONTANEOUS GASTROCOLONIC ADENOCARCINOMA OF WF-OSAKA RAT STRAIN

Monoclonal antibody against colon cancer inducing virus particles of WF-Osaka rat strain was yielded. Using monoclonal antibody, solid-phase immune electron microscopic study was carried out. Viable virus particles were disclosed from the supernatant of S3 medium, fixed by means of ultra microwave for 2 minutes. The size of these particles was approximately 40 to 50 nm in diameter, and the particles showed numerous spikes on the surface. Furthermore, transmission electron microscopy of transplantable gastric carcinoma and lymphoma revealed virus particles in their cytoplasm. We believe that this is the flrst report of virus inducing intestinal cancer among animals.