Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma

[ABSTRACT] Background: Airway mucus hypersecretion is an important pathophysiological feature of asthma. MUC5AC and MUC5B are the major secreted polymeric mucins in airways, and their compositions affect mucus properties. Despite the increasing appreciation of MUC5AC and MUC5B compositions in asthma...

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Veröffentlicht in:Allergology International 2022-04, Vol.71 (2), p.193-199
Hauptverfasser: Tomoko Tajiria, b, Hisako Matsumotoa, c, Makiko Jinnaia, Yoshihiro Kanemitsua, Tadao Nagasakia, Toshiyuki Iwataa, Hideki Inouea, Hitoshi Nakajia, Tsuyoshi Ogumaa, Isao Itoa, Akio Niimia
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Sprache:jpn
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Zusammenfassung:[ABSTRACT] Background: Airway mucus hypersecretion is an important pathophysiological feature of asthma. MUC5AC and MUC5B are the major secreted polymeric mucins in airways, and their compositions affect mucus properties. Despite the increasing appreciation of MUC5AC and MUC5B compositions in asthmatic airways, their pathophysiological relevance remains to be fully understood in humans. Methods: In this cross-sectional study, we prospectively enrolled newly referred steroid-untreated patients with mild asthma and healthy controls. We compared induced sputum MUC5AC and MUC5B levels between patients and controls. Subsequently, we assessed the correlation between MUC5AC and MUC5B levels and clinical indices in patients. Sputum MUC5AC and MUC5B levels were measured using enzyme-linked immunosorbent assays. Results: Sputum MUC5AC and MUC5B levels were significantly higher in patients (n=87) than in controls (n=22) (p=0.0002 and p=0.006, respectively). The ratio of sputum MUC5AC to MUC5B tended to be higher in patients than in controls (p=0.07). Sputum MUC5AC levels significantly and positively correlated with fractional exhaled nitric oxide at expiratory flow of 50mL/s (Spearman's rho=0.29, p=0.006), sputum eosinophil proportion (rho=0.34, p=0.0013), and airway sensitivity (rho=0.39, p=0.0005). By contrast, sputum MUC5B levels significantly and positively correlated with airway sensitivity (rho=0.35, p=0.002) and negatively correlated with airway reactivity (rho=-0.33, p=0.004). Conclusions: Sputum MUC5AC is increased by protein levels and involved in airway type 2/eosinophilic inflammation and airway hyperresponsiveness in steroid-untreated patients with mild asthma.
ISSN:1323-8930