Cultured human mast cells release various chemokines after stimulation with IL-33

Dear Editor, Both acquired and innate immune responses reportedly cause type 2 inflammation, the main pathogenesis underlying such allergic disorders as bronchial asthma. Crosstalk between acquired and innate immune responses involves various cell types and is a critical driver of type 2 inflammation. Among those cells, mast cells play unique roles as a result of being directly activated in both immune responses: acquired immune responses (IgE crosslinking) induce mast cells' degranulation and cytokine and cysteinyl LT production, while innate immune responses (IL-33 and TSLP) induce mast cells' cytokine production. Cytokines are some of the most important mediators in cell-to-cell interactions. In order to work effectively, cytokine-producing cells need to release chemokines that attract their target cells into close proximity. Regarding mast cells, IgE crosslinking reportedly leads to release of several chemokines.