Congenital Hypothyroidism with Ectopic Thyroid Gland in One Monozygotic Twin

Congenital Hypothyroidism with Ectopic Thyroid Gland in One Monozygotic Twin

The case of a monozygotic twin, discordant for congenital hypothyroidism, is reported. The monozygosity of the twins was established by typing for 23 different hematogenetic marker gene-systems, with DNA fingerprint analysis. The sublingual thyroid in this patient was probably due to an intrauterine...

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Veröffentlicht in:Clinical Pediatric Endocrinology 1993, Vol.2 (2), p.119-123
Hauptverfasser: Seigo Ono, Michiyo Mizota, Kiyoko Ootsubo, Hiroyuki Imanaka, Osao Tsuganezawa, Mamoru Ogata, Kazutoshi Ago
Format: Artikel
Sprache:jpn
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Zusammenfassung:The case of a monozygotic twin, discordant for congenital hypothyroidism, is reported. The monozygosity of the twins was established by typing for 23 different hematogenetic marker gene-systems, with DNA fingerprint analysis. The sublingual thyroid in this patient was probably due to an intrauterine disorder of unknown origin which spared his brother. This case supports the hypothesis that environmental, rather than genetic factors, are the cause of ectopic thyroid dysgenesis.
ISSN:0918-5739