Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative

Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative

Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20h at r.t., followed by pseudomerization in ice-water, gave a δ20(22) -pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2007, Vol.55 (7), p.1077-1078
Hauptverfasser: Sayaka MATSUSHITAa, Yoshihiro YANAIa, Asami FUSYUKUa, Yukio FUJIWARAa, Tsuyoshi IKEDAa, Masateru ONOb, Chunguang HANc, Makoto OJIKAc, Toshihiro NOHARAa
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Sprache:jpn
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Zusammenfassung:Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20h at r.t., followed by pseudomerization in ice-water, gave a δ20(22) -pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities.
ISSN:0009-2363