Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum

Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum

A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH2Cl2 fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2003-05, Vol.51 (5), p.605-607
Hauptverfasser: Xing Fu CAIa, Guanghai SHENa, Nguyen Tien DATa, Ok Hwa KANGb, Jin A KIMb, Young Mi LEEb, Jung Joon LEEc, Young Ho KIMa
Format: Artikel
Sprache:jpn
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH2Cl2 fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-α-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-α secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.
ISSN:0009-2363