Physicochemical Characterization and Toxicity of Decursin and Their Derivatives from Angelica gigas

Physicochemical Characterization and Toxicity of Decursin and Their Derivatives from Angelica gigas

Angelica gigas NAKAI is used to treat dysmenorrhea, amenorrhea, menopause, abdominal pain, injuries, migraine, and arthritis. The present study provided a physicochemical and toxicological characterization of compounds in A.gigas NAKAI (decursin, decursinol angelate, diketone decursin, ether decursi...

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Veröffentlicht in:Biological and Pharmaceutical Bulletin 2012-07, Vol.35 (7), p.1084-1090
Hauptverfasser: Bimit Mahat, Jung-woo Chae, In-hwan Baek, Gyu-yong Song, Jin-sook Song, Seong-kwon Cho, Kwang-il Kwon
Format: Artikel
Sprache:jpn
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Zusammenfassung:Angelica gigas NAKAI is used to treat dysmenorrhea, amenorrhea, menopause, abdominal pain, injuries, migraine, and arthritis. The present study provided a physicochemical and toxicological characterization of compounds in A.gigas NAKAI (decursin, decursinol angelate, diketone decursin, ether decursin, epoxide decursin and oxim decursin). Diketone decursin (173.16μg/mL) and epoxide decursin (122.12μg/mL) exhibited > 100μg/mL kinetic solubility after applying nephelometry, suggesting a highly soluble compound. The Student's t-test revealed significant differences in the pKa ranges of the compounds by automatic titration from capillary electrophoresis (p
ISSN:0918-6158