Preliminary Study of the Combination of Radiation Therapy, Chemotherapy, and Hyperthermia in Stage IIIB Cervical Carcinoma

We have planned to start a randomized trial in which concurrent chemotherapy add to radiotherapy, concurrent hyperthermia add to radiotherapy, and combining all these three modalities for advanced cervical carcinomas. In this preliminary study, we evaluated the clinical response and acute toxicity for three patients with FIGO Stage IIIB cervical carcinomas treated with combining all these three modalities. A complete response was achieved in 2 patients, and partial response in one patient. Grade 3 leukopenia occurred in 2 patients, Grade 2 in one patient. Grade 1 gastrointestinal and genitourinary toxicity were found in all patients. However, none of the patients had Grade 4 toxicity. Treatment with concurrent chemotherapy and hyperthermia add to definitive radiotherapy was shown to be effective in patients with FIGO Stage IIIB cervical carcinoma. In addition, a combination of all three modalities was well tolerated and had acceptable acute toxicity.