2D-03 Transcription regulation by FFRPs in Archaeal and Eubacterial cells6. Mechanism of regulating amino acid metabolism in Pyrococcus by combining archaeal FFRPs

Many Arcahaeal species in the genus Pyrococcus do not catalyze carbohydrates, if added to the media, but instead utilize amino acids. Pyrococcus OT3 has 14 FFRPs, and many of them interact with amino acids but differently. On the basis of such interactions and also of the DNA-binding specificity of these FFRPs, a possible mechanism of regulating amino acid metaboism for the growth of P. OT3 is discussed. A possibility of assembling FFRPs of different types will be included in the discussion, which will increase variations of DNA-binding specificity and ligand-selectivity created in combination.