Functional Compensation by Transplantation of Cell Suspensions of Embryonic Mesencephalon into the Striatum of Rats with 6-Hydroxydopamine Lesions

Functional Compensation by Transplantation of Cell Suspensions of Embryonic Mesencephalon into the Striatum of Rats with 6-Hydroxydopamine Lesions

Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out o...

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Veröffentlicht in:Japanese Journal of Pharmacology 1986, Vol.40 (4), p.591-593
Hauptverfasser: Hiroshi WATANABE, Yukitaka HIYAMA, Hiroshi SUDA, Shun-ichi SEKIHARA, Katsutoshi TERASAWA
Format: Artikel
Sprache:jpn
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Zusammenfassung:Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out of 64 rats. DOPA accumulation and dopamine level (6.3 and 3.4%. respectively, compared with those of uncompensated rats) in the striatum following treatment with an amino acid decarboxylase inhibitor were slightly restored in compensated rats.
ISSN:0021-5198