STIMULATORY EFFECT OF PLASMIN ON THE RELEASE OF HEPARAN SULFATE FROM VASCULAR ENNOTHELIAL CELLS IN CULTURE

STIMULATORY EFFECT OF PLASMIN ON THE RELEASE OF HEPARAN SULFATE FROM VASCULAR ENNOTHELIAL CELLS IN CULTURE

Vascular endothelial cells are important in the regulation of blood coagulation and fibrinolysis . Since thrombin stimulates the release of plasminogen activators from endothelial cells1) thrombin-stimulated cells will convert more plasminogen to plasmin. We hypothesized that plasmin produced from p...

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Veröffentlicht in:CONNECTIVE TISSUE 1992, Vol.23 (2), p.105-106
Hauptverfasser: Toshiyuki Kaji, Michiko Sakamoto, Fumitomo Koizumi
Format: Artikel
Sprache:jpn
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Zusammenfassung:Vascular endothelial cells are important in the regulation of blood coagulation and fibrinolysis . Since thrombin stimulates the release of plasminogen activators from endothelial cells1) thrombin-stimulated cells will convert more plasminogen to plasmin. We hypothesized that plasmin produced from plasminogen by plasminogen activators derived from thrombin-stimulated endothelial cells may affect their GAG metabolism. The present study was undertaken to clarify the effect of plasmin on the release of GAG from bovine aortic endothelial cells in a culture system
ISSN:0916-572X