The Clinical Presentation of Culture-positive and Culture-negative, Quantitative Polymerase Chain Reaction (qPCR)-Attributable Shigellosis in the Global Enteric Multicenter Study and Derivation of a Shigella Severity Score: Implications for Pediatric Shigella Vaccine Trials

The Clinical Presentation of Culture-positive and Culture-negative, Quantitative Polymerase Chain Reaction (qPCR)-Attributable Shigellosis in the Global Enteric Multicenter Study and Derivation of a Shigella Severity Score: Implications for Pediatric Shigella Vaccine Trials

BACKGROUND: Shigella is a leading cause of childhood diarrhea and target for vaccine development. Microbiologic and clinical case definitions are needed for pediatric field vaccine efficacy trials. METHODS: We compared characteristics of moderate to severe diarrhea (MSD) cases in the Global Enteric...

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Veröffentlicht in:Clinical Infectious Diseases 2021-08, Vol.73 (3)
Hauptverfasser: Pavlinac, Patricia B, Platts-Mills, James A, Tickell, Kirkby D, Liu, Jie, Juma, Jane, Kabir, Furqan, Nkeze, Joseph, Okoi, Catherine, Operario, Darwin J, Uddin, Jashim, Ahmed, Shahnawaz, Alonso, Pedro L, Antonio, Martin, Becker, Stephen M, Breiman, Robert F, Faruque, Abu SG, Fields, Barry, Gratz, Jean, Haque, Rashidul, Hossain, Anowar, Hossain, M Jahangir, Jarju, Sheikh, Qamar, Farah, Iqbal, Najeeha Talat, Kwambana, Brenda, Mandomando, Inacio, McMurry, Timothy L, Ochieng, Caroline, Ochieng, John B, Ochieng, Melvin, Onyango, Clayton, Panchalingam, Sandra, Kalam, Adil, Aziz, Fatima, Qureshi, Shahida, Ramamurthy, Thandavarayan, Roberts, James H, Saha, Debasish, Sow, Samba O, Stroup, Suzanne E, Sur, Dipika, Tamboura, Boubou, Taniuchi, Mami, Tennant, Sharon M, Roose, Anna, Toema, Deanna, Wu, Yukun, Zaidi, Anita, Nataro, James P, Levine, Myron M, Houpt, Eric R, Kotloff, Karen L
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Sprache:eng
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Zusammenfassung:BACKGROUND: Shigella is a leading cause of childhood diarrhea and target for vaccine development. Microbiologic and clinical case definitions are needed for pediatric field vaccine efficacy trials. METHODS: We compared characteristics of moderate to severe diarrhea (MSD) cases in the Global Enteric Multicenter Study (GEMS) between children with culture positive Shigella to those with culture-negative, quantitative polymerase chain reaction (qPCR)-attributable Shigella (defined by an ipaH gene cycle threshold
ISSN:1058-4838
DOI:10.1093/cid/ciaa1545