Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is su...

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Veröffentlicht in:Nature communications 2021-05, Vol.12 (1), p.2830
Hauptverfasser: Karabegović, Irma, Portilla-Fernandez, Eliana, Li, Yang, Ma, Jiantao, Maas, Silvana CE, Sun, Daokun, Hu, Emily A, Kühnel, Brigitte, Zhang, Yan, Ambatipudi, Srikant, Fiorito, Giovanni, Huang, Jian, Castillo-Fernandez, Juan E, Wiggins, Kerri L, de Klein, Niek, Grioni, Sara, Swenson, Brenton R, Polidoro, Silvia, Treur, Jorien L, Cuenin, Cyrille, Tsai, Pei-Chien, Costeira, Ricardo, Chajes, Veronique, Braun, Kim, Verweij, Niek, Kretschmer, Anja, Franke, Lude, van Meurs, Joyce BJ, Uitterlinden, André G, de Knegt, Robert J, Ikram, M Arfan, Dehghan, Abbas, Peters, Annette, Schöttker, Ben, Gharib, Sina A, Sotoodehnia, Nona, Bell, Jordana T, Elliott, Paul, Vineis, Paolo, Relton, Caroline, Herceg, Zdenko, Brenner, Hermann, Waldenberger, Melanie, Rebholz, Casey M, Voortman, Trudy, Pan, Qiuwei, Fornage, Myriam, Levy, Daniel, Kayser, Manfred, Ghanbari, Mohsen
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Sprache:eng
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Zusammenfassung:Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-22752-6