Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito f...

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Veröffentlicht in:The Journal of infectious diseases 2022-05, Vol.226 (4), p.708-713
Hauptverfasser: Rek, John, Blanken, Sara Lynn, Okoth, Joseph, Ayo, Daniel, Onyige, Ismail, Musasizi, Eric, Ramjith, Jordache, Andolina, Chiara, Lanke, Kjerstin, Arinaitwe, Emmanuel, Olwoch, Peter, Collins, Katharine A, Kamya, Moses R, Dorsey, Grant, Drakeley, Chris, Staedke, Sarah G, Bousema, Teun, Conrad, Melissa D
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Sprache:eng
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Zusammenfassung:Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32-1.92; P 
ISSN:0022-1899
DOI:10.1093/infdis/jiac169