Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Rationale: Whether patients with coronavirus disease (COVID-19) may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. Objectives: To estimate the effect of ECMO on 90-day mortality versus IMV only. Methods: Among...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2022-05, Vol.206 (3), p.281-294
Hauptverfasser: Hajage, David, Combes, Alain, Guervilly, Christophe, Lebreton, Guillaume, Mercat, Alain, Pavot, Arthur, Nseir, Saad, Mekontso-Dessap, Armand, Mongardon, Nicolas, Mira, Jean Paul, Ricard, Jean-Damien, Beurton, Alexandra, Tachon, Guillaume, Kontar, Loay, Le Terrier, Christophe, Richard, Jean Christophe, Mégarbane, Bruno, Keogh, Ruth H, Belot, Aurélien, Maringe, Camille, Leyrat, Clémence, Schmidt, Matthieu, COVID-ICU Investigators
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Sprache:eng
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Zusammenfassung:Rationale: Whether patients with coronavirus disease (COVID-19) may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. Objectives: To estimate the effect of ECMO on 90-day mortality versus IMV only. Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO versus no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 
DOI:10.1164/rccm.202111-2495OC