Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

UNLABELLED: In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positive...

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Veröffentlicht in:Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020-12, Vol.71 (12), p.3222-3225
Hauptverfasser: Bojang, Abdoulie, Baines, Sarah L, Camara, Bully, Guerillot, Romain, Donovan, Liam, Marqués, Raquel Sánchez, Secka, Ousman, D'Alessandro, Umberto, Bottomley, Christian, Howden, Benjamin P, Roca, Anna
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Sprache:eng
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Zusammenfassung:UNLABELLED: In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.
ISSN:1058-4838
DOI:10.1093/cid/ciaa609