Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Di...

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Veröffentlicht in:Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019-05, Vol.68 (12), p.2114-2116
Hauptverfasser: Porco, Travis C, Hart, John, Arzika, Ahmed M, Weaver, Jerusha, Kalua, Khumbo, Mrango, Zakayo, Cotter, Sun Y, Stoller, Nicole E, O'Brien, Kieran S, Fry, Dionna M, Vanderschelden, Benjamin, Oldenburg, Catherine E, West, Sheila K, Bailey, Robin L, Keenan, Jeremy D, Lietman, Thomas M, Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Rési
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Sprache:eng
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Zusammenfassung:In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.
ISSN:1058-4838
DOI:10.1093/cid/ciy973