Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel

Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes,...

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Veröffentlicht in:EMERGING INFECTIOUS DISEASES 2018-07, Vol.24 (7), p.1335-1339
Hauptverfasser: Behar, Adi, Baker, Kate Susan, Bassal, Ravit, Ezernitchi, Analia, Valinsky, Lea, Thomson, Nicholas R, Cohen, Daniel
Format: Artikel
Sprache:eng
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Zusammenfassung:Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes, and little genetic variation within the O antigen: highly relevant for Shigella vaccine development.
ISSN:1080-6040
DOI:10.3201/eid2407.171313