Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk

Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies (GWAS) of three mammographic density phenotypes: dens...

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Veröffentlicht in:	Nature communications 2014-10, Vol.5 (1)
Hauptverfasser:	Lindström, Sara, Thompson, Deborah J, Paterson, Andrew D, Li, Jingmei, Gierach, Gretchen L, Scott, Christopher, Stone, Jennifer, Douglas, Julie A, dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J, Loos, Ruth JF, Heit, John A, Pankratz, V Shane, Norman, Aaron, Goode, Ellen L, Cunningham, Julie M, deAndrade, Mariza, Vierkant, Robert A, Czene, Kamila, Fasching, Peter A, Baglietto, Laura, Southey, Melissa C, Giles, Graham G, Shah, Kaanan P, Chan, Heang-Ping, Helvie, Mark A, Beck, Andrew H, Knoblauch, Nicholas W, Hazra, Aditi, Hunter, David J, Kraft, Peter, Pollan, Marina, Figueroa, Jonine D, Couch, Fergus J, Hopper, John L, Hall, Per, Easton, Douglas F, Boyd, Norman F, Vachon, Celine M, Tamimi, Rulla M
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies (GWAS) of three mammographic density phenotypes: dense area, non-dense area and percent density in up to 7,916 women in stage 1 and an additional 10,379 women in stage 2. We identify genome-wide significant (P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms6303