Expectant management versus IUI in unexplained subfertility and a poor pregnancy prognosis (EXIUI study): a randomized controlled trial

STUDY QUESTION: For couples with unexplained subfertility and a poor prognosis for natural conception, is 6 months expectant management (EM) inferior to IUI with ovarian stimulation (IUI-OS), in terms of live births? SUMMARY ANSWER: In couples with unexplained subfertility and a poor prognosis for n...

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Veröffentlicht in:	Human Reproduction 2022-11, Vol.37 (12), p.2808-2816
Hauptverfasser:	Wessel, J.A., Mochtar, M.H., Besselink, D.E., Betjes, H., Bruin, J.P. de, Cantineau, A.E.P., Groenewoud, E.R., Hooker, A.B., Lambalk, C.B., Kwee, J., Kaaijk, E.M., Louwe, L.A., Maas, J.W.M., Mol, B.W.J., Rumste, M.M.E. van, Traas, M.A.F., Goddijn, M., Wely, M. van, Mol, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	expectant management intrauterine insemination IUI live birth randomized controlled trial RCT unexplained subfertility
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Zusammenfassung:	STUDY QUESTION: For couples with unexplained subfertility and a poor prognosis for natural conception, is 6 months expectant management (EM) inferior to IUI with ovarian stimulation (IUI-OS), in terms of live births? SUMMARY ANSWER: In couples with unexplained subfertility and a poor prognosis for natural conception, 6 months of EM is inferior compared to IUI-OS in terms of live births. WHAT IS KNOWN ALREADY: Couples with unexplained subfertility and a poor prognosis are often treated with IUI-OS. In couples with unexplained subfertility and a relatively good prognosis for natural conception (>30% in 12 months), IUI-OS does not increase the live birth rate as compared to 6 months of EM. However, in couples with a poor prognosis for natural conception (
DOI:	10.1093/humrep/deac236