Gottingen minipig is not a suitable animal model for in vivo testing of tissue-engineered corneal endothelial cell-carrier sheets and for endothelial keratoplasty

Aim: To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Gottingen minipigs and at the same time test the suitability of Gottingen minipig as model for endothelial keratoplasty. Materials and Methods: Cell-carrier constr...

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Veröffentlicht in:Current Eye Research 2020-01, Vol.45 (8), p.945-949
Hauptverfasser: Telinius, N., Spinozzi, D., Rasic, D., Dapena, I., Baandrup, U., Miron, A., Oellerich, S., Hjortdal, J.
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Sprache:eng
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Zusammenfassung:Aim: To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Gottingen minipigs and at the same time test the suitability of Gottingen minipig as model for endothelial keratoplasty. Materials and Methods: Cell-carrier constructs of decellularized HALC with cultured (pCEC) were created for implementation in vivo. Eight Gottingen minipigs (6 months old) underwent surgery with descemetorhexis or removal of endothelium by scraping and implementation of HALC without (animal 1-4) and with (animal 5-8) pCEC. Follow-up examinations included optical coherence tomography (OCT) imaging (1,2 and 3 months) and slit-lamp examination (
DOI:10.1080/02713683.2019.1706747