Role of rare and low-frequency variants in gene-alcohol interactions on plasma lipid levels

Role of rare and low-frequency variants in gene-alcohol interactions on plasma lipid levels

Background: Alcohol intake influences plasma lipid levels, and such effects may be moderated by genetic variants. We aimed to characterize the role of aggregated rare and low-frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting plasma lipid levels. Me...

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Veröffentlicht in:Circulation: Genomic and Precision Medicine 2020-08, Vol.13 (4), p.307-313
Hauptverfasser: Wang, Z., Chen, H., Bartz, T.M., Bielak, L.F., Chasman, D.I., Feitosa, M.F., Franceschini, N., Guo, X.Q., Lim, E., Noordam, R., Richard, M.A., Wang, H.M., Cade, B., Cupples, L.A., Vries, P.S. de, Giulanini, F., Lee, J., Lemaitre, R.N., Martin, L.W., Reiner, A.P., Rich, S.S., Schreiner, P.J., Sidney, S., Sitlani, C.M., Smith, J.A., Dijk, K.W. van, Yao, J., Zhao, W., Fornage, M., Kardia, S.L.R., Kooperberg, C., Liu, C.T., Mook-Kanamori, D.O., Province, M.A., Psaty, B.M., Redline, S., Ridker, P.M., Rotter, J.I., Boerwinkle, E., Morrison, A.C.
Format: Artikel
Sprache:eng
Schlagworte:
exome
gene-environment interaction
genome-wide association study
lipids
self-report
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Zusammenfassung:Background: Alcohol intake influences plasma lipid levels, and such effects may be moderated by genetic variants. We aimed to characterize the role of aggregated rare and low-frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting plasma lipid levels. Methods: In the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, fasting plasma triglycerides and high- and low-density lipoprotein cholesterol were measured in 34 153 individuals with European ancestry from 5 discovery studies and 32 277 individuals from 6 replication studies. Rare and low-frequency functional protein-coding variants (minor allele frequency,
DOI:10.1161/CIRCGEN.119.002772