Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

ScopeBody weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter‐individual variability in associations between body weight and dairy consumption. Methods and resultsA genome‐wide interaction study to discover genetic variants that account for variation in B...

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Veröffentlicht in:Molecular Nutrition & Food Research 2017-09, Vol.62 (3), p.1700347
Hauptverfasser: Smith, C.E., Follis, J.L., Dashti, H.S., Tanaka, T., Graff, M., Fretts, A.M., Kilpeläinen, T.O., Wojczynski, M.K., Richardson, K., Nalls, M.A., Schulz, C.A., Liu, Y., Frazier-Wood, A.C., Eekelen, E. van, Wang, C., Vries, P.S. de, Mikkilä, V., Rohde, R., Psaty, B.M., Hansen, T., Feitosa, M.F., Lai, C.Q., Houston, D.K., Ferruci, L., Ericson, U., Wang, Z., Mutsert, R., Oddy, W.H., Jonge, E.A.L. de, Seppälä, I., Justice, A.E., Lemaitre, R.N., Sørensen, T.I.A., Province, M.A., Parnell, L.D., Garcia, M.E., Bandinelli, S., Orho-Melander, M., Rich, S.S., Rosendaal, F.R., Pennell, C.E., Kiefte-de Jong, J.C., Kähönen, M., Young, K.L., Pedersen, O., Aslibekyan, S., Rotter, J.I., Mook-Kanamori, D.O., Zillikens, M.C., Raitakari, O.T., North, K.E., Overvad, K., Arnett, D.K., Hofman, A., Lehtimäki, T., Tjønneland, A., Uitterlinden, A.G., Rivadeneira, F., Franco, O.H., German, J.B., Siscovick, D.S., Cupples, L.A., Ordovás, J.M.
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Sprache:eng
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Zusammenfassung:ScopeBody weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter‐individual variability in associations between body weight and dairy consumption. Methods and resultsA genome‐wide interaction study to discover genetic variants that account for variation in BMI in the context of low‐fat, high‐fat and total dairy intake in cross‐sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta‐analyzed. Twenty‐six genetic variants reached the selected significance threshold (p‐interaction
DOI:10.1002/mnfr.201700347