The Rad23 ubiquitin receptor, the proteasome and functional specificity in transcriptional control

The proteasome has been implicated in transcriptional control in a bewildering number of ways, and many questions remain about how functional selectivity is conferred to its action. Here we discuss transcriptional roles for the ubiquitin receptor Rad23 and posit that such receptors may be key player...

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Veröffentlicht in:	Transcription 2010-07, Vol.1 (1), p.22-26
Hauptverfasser:	Wade, Staton L., Auble, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell Cycle DNA-Binding Proteins - metabolism Landes Organogenesis Point-of-Views Proteasome Endopeptidase Complex - metabolism Proteins Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Transcription, Genetic Ubiquitin - metabolism
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Zusammenfassung:	The proteasome has been implicated in transcriptional control in a bewildering number of ways, and many questions remain about how functional selectivity is conferred to its action. Here we discuss transcriptional roles for the ubiquitin receptor Rad23 and posit that such receptors may be key players dictating proteasome transcriptional specificity.
ISSN:	2154-1264 2154-1272
DOI:	10.4161/trns.1.1.12201