L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?

L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?

We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax ® )-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25,...

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Veröffentlicht in:Oncoimmunology 2012-11, Vol.1 (8), p.1422-1424
Hauptverfasser: DeGregorio, Michael, Wurz, Gregory T., Gutierrez, Audrey, Wolf, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Author's View
Binding
Biology
Bioscience
breast cancer
Calcium
Cancer
Cell
Cycle
L-BLP25
Landes
Letrozole
MMT model
Organogenesis
Proteins
Tamoxifen
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Zusammenfassung:We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax ® )-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.21129