A novel role for granzymes in anti-tumor immunity

A novel role for granzymes in anti-tumor immunity

The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical "eat-me" signals on the dying tumor...

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Veröffentlicht in:Oncoimmunology 2012-03, Vol.1 (2), p.219-221
Hauptverfasser: Hoves, Sabine, Sutton, Vivien R., Trapani, Joseph A.
Format: Artikel
Sprache:eng
Schlagworte:
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
cross-presentation
Cycle
cytotoxic T cells
dendritic cells
granzymes
Landes
Organogenesis
phagocytosis
Proteins
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Beschreibung
Zusammenfassung:The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical "eat-me" signals on the dying tumor cell, resulting in efficient phagocytosis of cell-associated tumor antigen.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.1.2.18102