Dietary Glycine Inhibits Angiogenesis During Wound Healing and Tumor Growth

In this study we investigated the effects of glycine on angiogenesis during embryogenesis, wound healing and tumor growth. In chorioallantoic membrane (CAM) assay, glycine (100 μM) inhibited angiogenesis by more than 50%. We studied dietary glycine's effect on fibrin induced wound healing respo...

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Veröffentlicht in:	Cancer biology & therapy 2003-03, Vol.2 (2), p.173-178
Hauptverfasser:	Amin, Khalid, Li, Jie, Chao, Wan Ru, Dewhirst, Mark W., Haroon, Zishan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allantois - chemistry Angiogenesis Inhibitors - administration & dosage Animals Binding Biology Bioscience Blotting, Western Calcium Cancer Cell Cell Division Chorion - chemistry Chorion - metabolism Cycle Diet Female Fibrin - metabolism Gels Glycine - administration & dosage Granulation Tissue - enzymology Granulation Tissue - metabolism Immunoenzyme Techniques Landes Mammary Neoplasms, Experimental - enzymology Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Organogenesis Proteins Rats Rats, Inbred F344 Wound Healing - drug effects
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Zusammenfassung:	In this study we investigated the effects of glycine on angiogenesis during embryogenesis, wound healing and tumor growth. In chorioallantoic membrane (CAM) assay, glycine (100 μM) inhibited angiogenesis by more than 50%. We studied dietary glycine's effect on fibrin induced wound healing response in a novel (Fibrin Z-chamber) assay. Fibrin within the chamber triggers the healing cascade leading to formation of granulation tissue (GT) rich in blood vessels and stroma. GT was reduced by more than 30% (p
ISSN:	1538-4047 1555-8576
DOI:	10.4161/cbt.2.2.280