Safety and quality of life with maintenance olaparib plus bevacizumab in older patients with ovarian cancer: subgroup analysis of PAOLA-1/ENGOT-ov25

Safety and quality of life with maintenance olaparib plus bevacizumab in older patients with ovarian cancer: subgroup analysis of PAOLA-1/ENGOT-ov25

BACKGROUND: In PAOLA-1/ENGOT-ov25, the addition of olaparib to bevacizumab maintenance improved overall survival in patients with newly diagnosed advanced ovarian cancer. We describe the safety profile and quality of life (QoL) of this combination in older patients in PAOLA-1. METHODS: Safety (CTCAE...

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Veröffentlicht in:ONCOLOGIST 2024-12
Hauptverfasser: Montegut, Coline, Falandry, Claire, Cinieri, Saverio, Cropet, Claire, Montane, Laure, Rousseau, Frederique, Joly, Florence, Moubarak, Malak, Mosconi, Anna M, Guerra-Alia, Eva M, Schauer, Christian, Fujiwara, Hiroyuki, Vergote, Ignace, Parma, Gabriella, Lindahl, Gabriel, Anota, Amelie, Canzler, Ulrich, Marme, Frederik, Pujade-Lauraine, Eric, Ray-Coquard, Isabelle, Sabatier, Renaud
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Sprache:eng
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Zusammenfassung:BACKGROUND: In PAOLA-1/ENGOT-ov25, the addition of olaparib to bevacizumab maintenance improved overall survival in patients with newly diagnosed advanced ovarian cancer. We describe the safety profile and quality of life (QoL) of this combination in older patients in PAOLA-1. METHODS: Safety (CTCAE v4.03) and QoL (EORTC QoL Questionnaires Core 30 and Ovarian 28) data were collected. We compared safety by age (≥70 vs 
ISSN:1083-7159