Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria

Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria

BACKGROUND: Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. METHODS AND RESULTS: A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male...

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Veröffentlicht in:JOURNAL OF THE AMERICAN HEART ASSOCIATION 2024-02, Vol.13 (3)
Hauptverfasser: Van den Eynde, Jef, Westenberg, Jos J.M, Hazekamp, Mark G, Lamb, Hildo J, Jongbloed, Monique R.M, Wentzel, Jolanda J, Kenjeres, Sasa, Dekkers, Ilona A, Van De Bruaene, Alexander, Rijnberg, Friso M, Roest, Arno A.W
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Sprache:eng
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Zusammenfassung:BACKGROUND: Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. METHODS AND RESULTS: A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular magnetic resonance assessment, including 4-dimensional flow imaging and computational fluid dynamics. Estimated glomerular filtration rate (eGFR) 3 mg/mmol in 39.6%. The average eGFR decline rate was -1.83 mL/min per 1.73 m2 per year (95% CI, -2.67 to -0.99; P
ISSN:2047-9980
2047-9980