Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors

BACKGROUND: Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 mon...

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Veröffentlicht in:	JOURNAL OF NEURO-ONCOLOGY 2023-06, Vol.163 (2), p.327-338
Hauptverfasser:	Biswas, Archita, Salvucci, Manuela, Connor, Kate, Dussmann, Heiko, Carberry, Steven, Fichtner, Michael, King, Ellen, Murphy, Brona, O'Farrell, Alice C, Cryan, Jane, Beausang, Alan, Heffernan, Josephine, Cremona, Mattia, Hennessy, Bryan T, Clerkin, James, Sweeney, Kieron J, MacNally, Steve, Brett, Francesca, O'Halloran, Philip, Bacon, Orna, Furney, Simon, Verreault, Maite, Quissac, Emie, Bielle, Franck, Ahmed, Mohammed H, Idbaih, Ahmed, Leenstra, Sieger, Ntafoulis, Ioannis, Fabro, Federica, Lamfers, Martine, Golebiewska, Anna, Hertel, Frank, Niclou, Simone P, Yen, Romain Tching Chi, Kremer, Andreas, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, Lambrechts, Diether, Purushothama, Manasa Kalya, Kel, Alexander, Byrne, Annette T, Prehn, Jochen H.M
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	BACKGROUND: Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 months, Long term survivors, LTS). METHODS: Patients were selected from an in-house cohort (GLIOTRAIN-cohort), using defined inclusion criteria (Karnofsky score > 70; age
ISSN:	0167-594X