A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

OBJECTIVE: To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), moderate intensity exercise (MIE), and resistance exercise (RE) while profiling counterregulatory hormones, lactate, ketones, and kinetic data in adults with type 1 diabetes. RESEARC...

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Veröffentlicht in:DIABETES CARE 2022-01, Vol.45 (1), p.194-203
Hauptverfasser: Paldus, Barbora, Morrison, Dale, Zaharieva, Dessi P, Lee, Melissa H, Jones, Hannah, Obeyesekere, Varuni, Lu, Jean, Vogrin, Sara, La Gerche, Andre, McAuley, Sybil A, MacIsaac, Richard J, Jenkins, Alicia J, Ward, Glenn M, Colman, Peter, Smart, Carmel E.M, Seckold, Rowen, King, Bruce R, Riddell, Michael C, O'Neal, David N
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Sprache:eng
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Zusammenfassung:OBJECTIVE: To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), moderate intensity exercise (MIE), and resistance exercise (RE) while profiling counterregulatory hormones, lactate, ketones, and kinetic data in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: This study was an open-label multisite randomized crossover trial. Adults with type 1 diabetes undertook 40 min of HIE, MIE, and RE in random order while using HCL (Medtronic MiniMed 670G) with a temporary target set 2 h prior to and during exercise and 15 g carbohydrates if pre-exercise glucose was
ISSN:0149-5992