Worsening in oxygen saturation and exercise capacity predict adverse outcome in patients with Eisenmenger syndrome

OBJECTIVES: To evaluate (1) changes in clinical, biochemical and echocardiographic parameters, (2) whether deterioration in exercise capacity and resting oxygen saturation (SatO2-rest) are related with adverse outcome and (3) its additional value in predicting outcome in Eisenmenger patients. METHODS: Seventy-seven (36±14years, 30% male) patients were included and prospectively followed. Changes between baseline and final visit were evaluated. Clinical deterioration was defined as a deterioration in exercise capacity or SatO2-rest. Univariate and multivariate analyses were performed to evaluate predictors of outcome defined as the need for hospitalization due to right heart failure, transplantation, or all-cause mortality. Finally, the additional prognostic value of deterioration in exercise capacity and SatO2-rest was evaluated. RESULTS: During a mean follow-up period of 4.0±2.1years, 27 (35%) events occurred. Patients in the event-group presented with an deterioration in NYHA class (P