Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

OBJECTIVE: The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD. DESIGN: The study cohort comprises 1339 biopsy-pro...

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Veröffentlicht in:GUT 2021-02, Vol.71 (2), p.382-390
Hauptverfasser: Younes, Ramy, Govaere, Olivier, Petta, Salvatore, Miele, Luca, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, McLeod, Duncan, Pareja, Maria Jesus, Fracanzani, Anna Ludovica, Aller, Rocio, Rosso, Chiara, Ampuero, Javier, Gallego-Duran, Rocio, Armandi, Angelo, Caviglia, Gian Paolo, Zaki, Marco Y.W, Liguori, Antonio, Francione, Paolo, Pennisi, Grazia, Grieco, Antonio, Birolo, Giovanni, Fariselli, Piero, Eslam, Mohammed, Valenti, Luca, George, Jacob, Romero-Gomez, Manuel, Anstee, Quentin Mark, Bugianesi, Elisabetta
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Sprache:eng
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Zusammenfassung:OBJECTIVE: The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD. DESIGN: The study cohort comprises 1339 biopsy-proven NAFLD subjects from four countries (Italy, UK, Spain and Australia), stratified into lean and non-lean (body mass index (BMI)
ISSN:0017-5749